![]() If you clap hard enough, your hands will hurt. Grotberg: Well, for a sound to be created, a mechanical event must occur, like clapping your hands. You’ve found that sounds could represent more than just the presence of a disease. Pulmonary edema is a common example, often a byproduct of heart failure. Crackles, on the other hand, are only heard by a stethoscope and are a sign of too much fluid in the lung. Patients who wheeze can be so loud you can hear it standing next to them. Grotberg: Typically, wheezing is found in asthma and emphysema. These wheezes and crackles are signs of what diseases? There are normal sounds of air movement, but also there can be abnormal sounds, like wheezes during expiration (breathing out) and crackles during inspiration (breathing in). For the lungs, typically the patient is asked to breathe in and out deeply. Grotberg: Two important organs being monitored are the heart and the lungs. When doctors pull out a stethoscope, what are they listening for? He answered some questions about the research. And they represent a paradigm shift for how doctors understand what they hear through a stethoscope. The findings could eventually change how lung diseases are treated, he says. Exploring this in humans is a research goal. His conclusion is based on evidence from experiments on microfluidic chips and on animal models. James Grotberg, professor of biomedical engineering at the College of Engineering and professor of surgery at the Medical School, recently published a study describing how the mechanics that produce those noises with every breath are likely a cause of injury and inflammation. ![]()
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